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Wheat is most cultivated cereal of Nepal after rice and maize because of its multiple uses. Wheat is staple food for many developing countries. Whatever it’s uses, the yield loss has become one the important concern for today’s breeders and researchers. In Nepal, wheat is grown under rainfed condition and hence, is more susceptible to drought. Drought stress plays significant role in yield loss. During the course of phenological cycle, the crop evapotranspiration increases and reaches a maximum in the growth stage (from the beginning of heading to the end of flowering), which is the most sensitive stage of the wheat crop to drought. Drought brings various morphological, physiological, biochemical, genetics variations which has direct or indirect correlation with yield. Many researchers and breeders are working to develop drought tolerant genotypes to withstand drought Wheat breeding programs aim to reorganize genotypes possessing improved yields adaptation to changing climatic conditions and a balanced food quality.