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The purpose of this experiment is to study the combined effect of frequency of weeding and integrated nutrient management on the growth and yield of transplant aman rice (cv. BRRI dhan49). The experiment consisted of five weeding regimes and four integrated nutrient managements. The experiment was laid out in a randomized complete block design with three replications. The highest grain yield (5.80 t ha-1) was obtained from the interaction between weed free and 25% BRRI RD + 75% N from CD which was followed by the applications of pre-emergence herbicide + one hand weeding at 35 DAT and 25% BRRI RD + 75% N from CD treatment. The lowest grain (3.65 t ha-1) was found from the interaction between no weeding and BRRI recommended chemical fertilizers.The degree of statistical relationship between grain yield and number of effective tillers/hill, grain yield and straw yield of BRRI dhan49 exhibited positive relationship. From the results of the study it can be concluded that the application of 25% BRRI RD + 75% N from CD in weed free condition might be used for obtaining the best performance of BRRI dhan49.